Friday, April 26, 2013

Putin: Boston bombing shows West's mistake

MOSCOW (AP) ? The Boston bombings should spur stronger security cooperation between Moscow and Washington, Russian President Vladimir Putin said Thursday, adding that they also show that the West was wrong in supporting militants in Chechnya.

Putin said that "this tragedy should push us closer in fending off common threats, including terrorism, which is one of the biggest and most dangerous of them."

The two brothers accused of the Boston bombings are ethnic Chechens who had lived in the U.S. for more than a decade.

Putin warned against trying to find the roots for the Boston tragedy in the suffering endured by the Chechen people, particularly in mass deportations of Chechens to Siberia and Central Asia on Soviet dictator Josef Stalin's orders. "The cause isn't in their ethnicity or religion, it's in their extremist sentiments," he said.

Speaking in an annual call-in show on state television, Putin criticized the West for refusing to declare Chechen militants terrorists and for offering them political and financial assistance in the past.

"I always felt indignation when our Western partners and Western media were referring to terrorists who conducted brutal and bloody crimes on the territory of Russia as rebels," Putin said.

The U.S. has urged the Kremlin to seek a political settlement in Chechnya and criticized rights abuses by Russian troops during the two separatist wars since 1994, which spawned an Islamic insurgency that has engulfed the entire region.

It also provided humanitarian aid to the region during the high points of fighting there in the 1990s and the early 2000s.

Russian officials have repeatedly claimed that rebels in Chechnya have close links with al-Qaida. They say dozens of fighters from Arab countries trickled into the region during the fighting there, while some Chechen militants have gone to fight in Afghanistan.

Putin said the West should have cooperated more actively with Russia in combatting terror.

"We always have said that we shouldn't limit ourselves to declarations about terrorism being a common threat and engage in closer cooperation," he said. "Now these two criminals have proven the correctness of our thesis."

Source: http://news.yahoo.com/putin-boston-bombing-shows-wests-mistake-101701441.html

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Thursday, April 25, 2013

Tuesday, April 23, 2013

Monday, April 22, 2013

Walking Your Way To Total Health And Fitness

How much do you really know about nutrition? Are you currently working on a nutrition plan that works for you? Would you like to make it better? Do you feel certain you are getting everything your body needs? If you having trouble answering the questions, follow the tips given.

Processed grains typically taste much better than whole grains do. There is some truth the idea that some flours, particularly white ones, are better for baked goods. But whole grains, in general, provide far more taste than the over-milled grains, and aid digestion through their fiber content.

TIP! Without a menu you may be tempted to eat something unhealthy. When your diet consists of many different types of meals, you avoid getting sick of one particular food and are more likely to stick with your diet.

To improve your overall nutrition you should eat a lot of whole grains. When you eat whole grains you actually become more healthy then people who eat a lot of refined carbohydrates. Include 100% whole wheat bread, brown rice, and whole wheat pasta in your daily food intake. Your digestive tract will thank you for eating whole grains by functioning well. Whole grains also provide a steadier energy supply. Refined carbohydrates give a quick burst of energy and a spike in glucose levels, but this is followed by a quick decline in energy.

You should eat plenty of foods rich in calcium. Dark-colored leafy vegetables, almonds and other nuts, and milk and cheese all provide a healthy amount of calcium to your diet. Sardines and soy milk are good sources of calcium, too. Calcium is important for growing strong bones and sturdy teeth. When you don?t have enough calcium, your bones can become brittle in a problem known as osteoporosis. Osteoporosis starts slowly, but can quickly progress into a serious illness leading to weak bones.

It is always best to steam or eat your foods raw, because cooking them can take away some or all of their nutritional value. Cooking strips nutrients from foods, which means that you don?t get the entire nutritional benefit of a food when you eat it cooked. This is particularly true for fruits and vegetables, and therefore you should try to eat these as close to their original form as possible.

TIP! Excellent nutrition is just a matter of counting to five. This represents how many individual servings of fruit and vegetables ought to be eaten daily.

Some low fat diet foods are high in sugar, and possibly also sugar substitutes, to replace the flavor lost in lowering the fat content. For foods that have a low amount of calories, you should discover what is actually in these foods.

The soft nature of an eggplants offers a great background for dishes such as eggplant parmesan and baba ghanoush. Not only is it a delicious food, it also contains folic acid, potassium, manganese and antioxidants.

Exercising involves mind strength, commitment and endurance. One way to improve you mindset is by eating well, setting goals and thinking positively. If you expect to exercise successfully, you will make sure your mind is in the right place. There is nothing more important that living the healthy life, which, after all, benefits the mind.

TIP! When you want to eat healthier, is is good to focus on specific actions you can take during the journey. Try to steer clear of fried foods, as these can be detrimental to your health.

Record your progress in a daily journal or notebook. This includes things like your blood pressure. In the same manner, if weight was previously an issue, make a note of both the pounds and inches that you lose through a healthy diet.

Multivitamins are good for supplements but are not replacements for nutritious foods. It?s important that you get nutrients from food as well. It is not a good idea to take more than one all-purpose multivitamin daily, unless your doctor has advised otherwise. Taking lots of vitamin supplements can actually throw off your body?s homeostasis.

A cereal filled with sugar is not a healthy breakfast. Aside from sugar, these cereals contain added chemicals, trans fat and preservatives. Making the switch to oatmeal is an excellent source of a quick and easy breakfast that will help you to feel full longer through the day than the cold cereal.

TIP! It is important to eat healthy fats each and every day. The healthy fats category does not include fats found in fast food and other tasty treats.

Do you like fruit? How about fruit juice? Try getting a juicer and making your own fresh juice, right in your kitchen. Adding vegetables to your juice gives it an extra kick. The sky is the limit on what you can make. Just pick your favorite fruits and vegetables and start juicing! Go wild with hot peppers to give your drinks a zesty touch.

Do you know more about nutrition than you did before? What is the status of your current nutrition plan? Are you able to decide what foods your body needs? Can your diet do more to support your body? The tips in the above article can help you with some of your fitness questions.

Consuming adequate amounts of water is imperative for any person desiring good health. The majority of the human body is water, so it is critical to consume enough. Try to drink a minimum of eight glasses of water every single day.

TIP! You need not sacrifice taste just because you want to cut fat and cholesterol. There are ways to prepare healthier versions of your favorite dishes, including lasagna.

Source: http://www.minbaitak.com/walking-your-way-to-total-health-and-fitness

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Low-dose aspirin stymies proliferation of two breast cancer lines

Apr. 21, 2013 ? Regular use of low-dose aspirin may prevent the progression of breast cancer, according to results of a study by researchers at the Veterans Affairs Medical Center in Kansas City, Mo., and the University of Kansas Medical Center.

The study found that aspirin slowed the growth of breast cancer cell lines in the lab and significantly reduced the growth of tumors in mice. The age-old headache remedy also exhibits the ability to prevent tumor cells from spreading.

The lead author of the study, Gargi Maity, a postdoctoral fellow who works in the cancer research unit at the VA Medical Center, will present the team's findings on Sunday, April 21, at the annual meeting of the American Society for Biochemistry and Molecular Biology, which is being held in conjunction with the Experimental Biology 2013 conference in Boston. The senior author is Sushanta Banerjee, director of the cancer research unit and a professor at the University of Kansas Medical Center in Kansas City, Kan.

The role of aspirin, or acetylsalicylic acid, in preventing and treating cancer has intrigued researchers since the late 1980s, when an Australian study found that people who regularly used aspirin were less likely to develop colorectal cancer. Aspirin use also has been shown to reduce the risk of squamous cell esophageal cancer and prostate cancer.

Anecdotal evidence indicated that breast cancer was less likely to return in women who took aspirin to lower their risk of heart attack or stroke. But the science behind this relationship is not well understood.

The VA study found that aspirin may interfere with cancer cells' ability to find an aggressive, more primordial state. In the mouse model the researchers used, cancer cells treated with aspirin formed no or only partial stem cells, which are believed to fuel the growth and spread of tumors.

Banerjee, a professor of medicine in division of hematology and oncology, says first-line chemotherapy treatments do not destroy stem cells. Eventually, the tumor will grow again. "If you don't target the stemness, it is known you will not get any effect," he says. "It will relapse."

In lab tests, aspirin blocked the proliferation of two different breast cancer lines. One of the lines tested is often called triple-negative breast cancer, a less common but more difficult treat form of the disease. "We are mainly interested in triple negative breast cancer, because the prognosis is very poor," Banerjee says.

Triple-negative breast cancers, which will be addressed in a special thematic program at the ASBMB annual meeting, lack receptors for estrogen, progesterone and Her2. Aspirin also may improve the effectiveness of current treatments for women whose breast cancers are hormone-receptor positive. In the team's study, aspirin enhanced the effect of tamoxifen, the usual drug therapy for hormone-receptor positive breast cancer.

Aspirin is used in the treatment of a number of different conditions. Banerjee says its ability to attack multiple metabolic pathways is what makes it potentially useful in the fight against cancer. "Cancer is not a single-gene disease," he says. "Multiple genes are involved."

Aspirin is a medicine with side effects, including gastrointestinal bleeding. Researchers will continue to explore if the positive effects of regular use of the drug outweigh the risks. In 2012, the National Cancer Institute asked scientists to design studies that would illuminate the mechanisms by which aspirin and drugs with other uses appear to reduce the risk of cancer or improve the prognosis for those diagnosed with the disease. Banerjee says his lab will apply for one of the grants.

Other co-authors at the cancer research unit include Snigdha Banerjee, associate professor of medicine in hematology and oncology at KU, and postdoctoral scholars Archana De and Amlan Das.

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The above story is reprinted from materials provided by American Society for Biochemistry and Molecular Biology (ASBMB), via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/O6RFShvmszU/130421151610.htm

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Rich political novice the favorite to win Paraguayan presidency

By Daniela Desantis and Hilary Burke

ASUNCION (Reuters) - Paraguayans go to the polls on Sunday in a presidential election that could return the center-right Colorado Party to power less than a year after the nation's leftist leader was impeached.

Millionaire businessman Horacio Cartes, 56, is the Colorado Party candidate and front-runner in the race, most polls show. A political novice, he vows to reform his party, which was tainted by corruption during its 60-year reign through 2008.

His main rival is Efrain Alegre, a 50-year-old lawyer and career politician in the ruling center-right Liberal Party, which took over the presidency after withdrawing support for President Fernando Lugo and clearing the way for his impeachment in June.

Congress ousted Lugo, a leftist and former Roman Catholic bishop, after finding him guilty of mishandling a botched land eviction that killed 17 police officers and peasant farmers. Some of Paraguay's neighbors saw the two-day trial as tantamount to a coup and imposed diplomatic sanctions on the South American nation.

"They're all the same to me, the Colorados, the Liberals, Lugo's people. I used to have faith in politicians but I don't anymore. What we need is jobs and they promise that but never deliver," said Evelia Benitez, a 38-year-old street vendor in the capital Asuncion.

Nearly 40 percent of Paraguay's 6.6 million people are poor. Located in the heart of the continent, the country relies on soybean and beef exports, but is also notorious for contraband trade and illicit financing.

One of Paraguay's wealthiest men, Cartes made his fortune in the financial and tobacco industries. Rivals have tried to link him to drug running and money laundering, but he has never been convicted of a crime and denies any wrongdoing.

Brash and outspoken, Cartes won support for his candidacy even though he never voted before joining the Colorado Party in 2009.

Alegre, a more somber politician, led corruption probes in Congress. But his reputation as an honest administrator has been undermined by an investigation into whether he misappropriated state funds while serving as Lugo's public works minister.

Paraguay's current president, Federico Franco, was barred from running in the presidential election under the country's constitution.

"My leadership model is different from the traditional one. My project represents a 'decent Paraguay' versus the 'Paraguay of the mafias,'" Alegre told Reuters in a recent interview.

BUCKING THE TREND

Polls open at 7 a.m. (1100 GMT). There is no second round of balloting so the candidate with the most votes will be declared the winner. Voters also will elect local authorities and members of Congress, with the left expected to gain seats in the divided legislature.

Paraguay will have a center-right government regardless of whether the Colorados or Liberals win, bucking the trend in South America where leftists have made steady gains in recent years. Only Colombia and Chile are ruled by conservatives.

The leftist bloc is especially strong in the Mercosur trade group, whose members include Brazil, Argentina, Uruguay and Venezuela. Mercosur suspended Paraguay after Lugo's impeachment and brought in socialist Venezuela, even though its inclusion was never approved by Paraguay's Congress.

Both Cartes and Alegre have said they would push for Paraguay's full return to Mercosur.

The country's economy has been on a roller-coaster ride and hinges largely on crop weather. It is expected to grow 13 percent this year after a severe drought caused a contraction in 2012, according to central bank forecasts.

Land conflicts have intensified in recent years and clashes occasionally break out between squatters and big landowners, including Brazilian soy farmers who live in Paraguay.

Cartes and Alegre promise to carry out agrarian reform. They also want to attract up to $2.7 billion in private capital to refurbish Paraguay's airports and build new highways, and they have vowed to improve operations at state-run companies.

They also agree that the bloated state bureaucracy, which employs about 10 percent of all workers, needs to be revamped.

"Both candidates have a 1990s sort of vision about administering the state in the sense that they would privatize or give concessions to the private sector, which goes against the grain of what's happening elsewhere in the region," said Guzman Ibarra, a political analyst at Seeds for Democracy, a non-profit group.

(Additional reporting by Mariel Cristaldo; Editing by Paul Simao)

Source: http://news.yahoo.com/rich-political-novice-favorite-win-paraguayan-presidency-050255324--business.html

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Sunday, April 21, 2013

Red Sox and Bruins ready to resume play Saturday

Fans hold up a sign during the second period of an NHL hockey game between the Boston Bruins and the Buffalo Sabres in Boston Wednesday, April 17, 2013. (AP Photo/Elise Amendola)

Fans hold up a sign during the second period of an NHL hockey game between the Boston Bruins and the Buffalo Sabres in Boston Wednesday, April 17, 2013. (AP Photo/Elise Amendola)

A Boston Bruins jersey with the number of Boston's area code and the words "Boston Strong" hangs in the locker of Bruins player Jay Pandolfo at TD Garden in Boston, Wednesday, April 17, 2013, after an NHL hockey game against the Buffalo Sabres in the aftermath of Monday's Boston Marathon bombings. (AP Photo/Jimmy Golen)

Boston Bruins hockey starters, including defenseman Dennis Seidenberg (44), stand next to a ribbon projected onto the ice at TD Garden in Boston, Wednesday, April 17, 2013, during a pregame ceremony in the aftermath of Monday's Boston Marathon bombings. (AP Photo/Elise Amendola)

(AP) ? The Red Sox and Bruins were ready to return to action after a daylong manhunt for a suspect in the Boston Marathon bombings brought major pro sports in the city to a standstill.

The Red Sox play the Kansas City Royals on Saturday afternoon following the postponement of Friday night's opening game of the scheduled three-game series at Fenway Park. No makeup date was announced.

The Bruins face the Pittsburgh Penguins, also on Saturday afternoon, in a meeting of two of the top four teams in the Eastern Conference. The game had been postponed from Friday night. The Penguins' scheduled home game against the Buffalo Sabres on Saturday night was rescheduled for Tuesday night.

The postponements came about four hours before the games were to start after authorities told people throughout Boston and some of its suburbs to stay indoors while they searched for the suspect. About three hours later, mass transit train service that had been shut down for much of Friday resumed.

Police had identified two suspects in Monday's bombings near the finish line of the marathon. One man was killed early Friday during a shootout with police. The other was taken into custody Friday night following a standoff during which shots were fired.

Boston College canceled all home athletic events for Saturday, including the annual spring football game.

The suspension of Amtrak train service forced the New England Revolution of MLS to change plans and travel by bus Friday morning for their game against the New York Red Bulls on Saturday night at Red Bull Stadium in Harrison, N.J.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-20-Marathon-Bombing-Boston-Sports/id-1028c28bc0d74a96a36a15666714faa0

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This week on gdgt: Razer's Edge isn't quite sharp enough

This week on gdgt

Each week, our friends at gdgt go through the latest gadgets and score them to help you decide which ones to buy. Here are some of their latest picks -- along with a few you should probably avoid. Want more? Visit gdgt anytime to catch up on the latest, and subscribe to gdgt's newsletter to get a weekly roundup in your inbox.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/SpJij5utrbI/

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Saturday, April 20, 2013

HTC One developer edition and unlocked editions delayed

HTC One

E-mail notification says 'slight delay' in shipping; cases won't hit until mid-May

Uh oh. If you ordered the 32GB unlocked or 64GB developer version of the HTC One directly from HTC (via Let's Talk), you might have just received the same e-mail we did, indicating some sort of delay.

Hello Phil

We have an important update about your order. Due to shipping issues with the 32G unlocked and 64G Developers Editions of the New HTC One®, there will be a slight delay in shipping your HTC One® to you. We expect to have your phone delivered to you, via overnight shipping, before the end of April. We’ll do everything we can to get it shipped to you as soon as possible.

Also, due to overwhelming demand, there will be a delay in shipping your free case. We expect to begin receiving the Double Dip cases in mid-May, and will ship them as soon as they’re available.

We understand the excitement and anticipation that comes with a new phone, and we are confident that the HTC One® will exceed that anticipation

Thanks for the support,

HTC ShopAmerica

That's no bueno, especially since HTC has had a couple dates -- April 18 and April 23 -- listed thus far, and no new shipping date is listed here. And that's to say nothing of the HTC One facing a global delay from March in the first place.

We're gonna rattle some bushes and see what we can find out. Stay tuned.

More in the HTC One forums.

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/MUbHxv2ZBsE/story01.htm

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GE trims profit outlook, raising concerns on Wall Street

By Ernest Scheyder

(Reuters) - General Electric Co cut the profit growth estimate for its core industrial businesses on Friday, citing weakness in Europe and sliding wind turbine sales, unnerving Wall Street and pushing its stock down in morning trading.

The world's biggest maker of jet engines and electric turbines now expects industrial profit to rise by high single digits to double digits this year. Previously it had forecast double-digit growth.

Chief Executive Jeff Immelt blamed slumping sales of wind turbines and gas turbines for the outlook cut, as well as the weakening European economy. But he said he still expects overall earnings, which include GE Capital, to improve this year.

Wall Street analysts, which earlier in the day hailed GE's better-than-expected first-quarter revenue, grew unnerved as the new outlook was disclosed in a conference call. Shares of GE dropped 4 percent to $21.76 in morning trading.

"The level of uncertainty in terms of their ability to meet their goals has risen a little bit," said Perry Adams, portfolio manager at Northwestern Bank, which holds GE shares.

GE sold 584 wind turbines in the first quarter, down 15 percent from a year earlier, due in part to a delay in the renewal of a federal tax credit for buyers in renewable energy. Profit in the power & water unit - which sells wind turbines - fell 39 percent, and results aren't expected to improve.

"We believe it's going to be hard for our power and water business in 2013 to meet 2012" results, Immelt said on the conference call.

Europe also remains a weak spot for the company - Immelt said sales there were "weaker than expected" - and could drag on 2013 profit, GE said.

REVENUE BEATS

Strong sales of jet engines and home appliances helped GE's first-quarter revenue beat expectations, assuaging fears of a miss after a lukewarm report on March U.S. factory activity.

GE said revenue rose slightly to $35 billion, surpassing the $34.51 billion analysts had expected, according to Thomson Reuters I/B/E/S.

"That is a beat on revenue, and that's important because the Street has been very worried about revenue numbers at industrial firms because the quarter appears to have tailed off in March," said Jack DeGan, chief investment officer at Harbor Advisory Corp in Portsmouth, New Hampshire, which owns GE shares.

The Institute for Supply Management said earlier this month that U.S. factory activity grew at the slowest rate in three months in March, suggesting the economy lost some momentum at the end of the first quarter.

GE shipped 596 commercial jet engines during the quarter, boosting profit at the aviation unit by 9 percent. The company also touted a recent contract with Boeing Co to supply engines for the 777 aircraft.

Despite price increases, consumers gobbled up GE's refrigerators, stoves and microwaves, boosting profit in the home and business solutions unit by 39 percent.

The company's order backlog - a closely watched indicator of future sales - rose to $216 billion from $210 billion in the fourth quarter of 2012. Backlog can be a positive sign that customers are willing to wait in line for a company's products, or a sign that a company is having a hard time meeting demand. GE's backlog has grown consistently in recent quarters.

"To me, when you see a trend, year over year, repeating itself, there's a business management issue. Eventually, that's got to change," said Oliver Pursche, president of Gary Goldberg Financial Services, which owns GE shares.

GE said it will slash costs by $1 billion this year, part of an effort to offset weak sales.

Fairfield, Connecticut-based GE said it earned $3.53 billion, or 34 cents per share, in the first quarter, compared with $3.03 billion, or 29 cents per share, a year earlier.

Excluding one-time items, profit was 35 cents per share, matching analysts' average forecast, according to Thomson Reuters I/B/E/S.

DIVIDEND

GE sold its remaining 49 percent stake in NBC Universal in February and then announced it would use cash from the sale to fund $18 billion in buybacks and dividend payouts this year.

The $18 billion figure includes $10 billion of shares the company plans to buy back and GE's dividend, which the company hiked in December by 12 percent to 19 cents per share quarterly.

The NBC sale helped GE's cash balance jump to $138.1 billion from $125.9 billion in the fourth quarter of 2012. The rise has led some investors to hope for yet another dividend hike.

"I expect it (dividend increase) to go from 19 cents to 21 cents ... but I don't expect it this quarter. Maybe next quarter," DeGan said.

On the conference call, Immelt said he remains committed to the plan to remunerate shareholders this year with $18 billion in buybacks and dividends. The company's annual meeting with shareholders is scheduled for New Orleans next week, and some investors said they expect a dividend announcement then.

Prior to selling NBC, GE had focused much of its efforts in recent years on scaling back its financial arm, making it less dependent on short-term funding and focusing more closely on a handful of operations, such as financing the sale of industrial equipment and lending money to mid-sized businesses.

GE has said it wants to grow its manufacturing and industrial units, a return to its roots. Earlier this month it bought oilfield pump maker Lufkin Industries Inc for $2.98 billion, boosting its presence in the fast-growing market to extract oil and natural gas from shale rock.

(Reporting By Ernest Scheyder; Additional reporting by Ryan Vlastelica, Patricia Kranz and Chuck Mikolajczak; Editing by Lisa Von Ahn and John Wallace)

Source: http://news.yahoo.com/ge-trims-profit-outlook-raising-concerns-wall-street-145525320--sector.html

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Obama goes from scolder in Washington to comforter in Boston

In Washington, President Obama is locked in a battle with many voices in Congress over gun control, but at a moment of national tragedy, such as the Boston Marathon bombings, the president stands alone.

By Howard LaFranchi,?Staff writer / April 18, 2013

President Obama speaks at an interfaith memorial service for the victims of the bombing at the Boston Marathon at the Cathedral of the Holy Cross in Boston on Thursday.

Brian Snyder/Reuters

Enlarge

A day after he stood in the White House Rose Garden as a frustrated scolder-in-chief, President Obama was in Boston Thursday assuming the role of comforter-in-chief at a prayer service for the victims of the Boston Marathon bombings.

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In both cases, Mr. Obama was acting to address, though in very different ways, horrendous acts of violence that stunned the country.

On Wednesday afternoon, with Gabrielle Giffords and Sandy Hook families at his side, the president cast ?shame? on the US Senate for rejecting a bipartisan plan for tighter background checks on gun purchases. Not 24 hours later, he was providing balm to the victims of an ?act of terror? and to a city struck in its heart.

In just a day, the president changed out of the political cloak of irate reaction to Congress to the higher m?antle of national leadership in times of grief. As Obama hugged families and visited the bedsides of the recovering, it only underscored how a presidential presence that meant so little one day in Washington could mean everything in Boston the next.?

It was a change in roles reminiscent of one made by President Clinton in 1996, when the Oklahoma City bombing ? at that time, the largest act of terror to strike the US ? allowed a president caught up in daily political harangues with Congress to step out from Washington and comfort a nation with what would become his trademark empathy.

In the Rose Garden, Obama was introduced by Mark Barden, who lost his son, Daniel, in the Sandy Hook Elementary School shooting on Dec. 14. With the president?s hand on his shoulder, Mr. Barden said the Sandy Hook families were ?disappointed? by the Senate votes but ?not defeated,? promising continued effort for gun safety legislation.

?All in all, this was a pretty shameful day for Washington,? Obama said.

In Boston, the president was accompanied by Michelle Obama, and the tone was much more one of comfort and of faith in the resilience of Boston and all Americans in the face of tragedy.

Comparing the nation to the Boston Marathon runner seen on videotape by millions as he was knocked off his feet by the first of two blasts, Obama said, ?We may be momentarily knocked off our feet. But we?ll pick ourselves up. We will keep going. We will finish the race.?

A devoted sports fan, Obama is said to have penned much of Thursday?s remarks himself.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/piKFqZKG_4k/Obama-goes-from-scolder-in-Washington-to-comforter-in-Boston

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Wednesday, April 17, 2013

Rain brings flood worries in Mo., Ill., Iowa

ST. LOUIS (AP) ? The Mississippi River, so low for much of the winter that barge traffic was nearly halted, could reach up to 10 feet above flood stage by the middle of next week in parts of Iowa, Illinois and Missouri, National Weather Service hydrologists said Wednesday.

The weather service is predicting 3 to 4 inches of rain ? and perhaps more ? from Kansas City, Mo., to Chicago by Friday morning, the result of an unsettled weather pattern that prompted widespread tornado and thunderstorm watches. Soil is already saturated from an unusually wet early spring, raising concerns along the Mississippi from the Quad Cities, which are along the Iowa-Illinois border, south to St. Louis.

"I'm worried," said Mark Fuchs, a National Weather Service hydrologist in suburban St. Louis. "Major flooding appears to be on the table at a lot of locations. North of St. Louis, we're looking at the kind of flooding we haven't seen since 2008."

Floods in the spring of 2008 were particularly troublesome in Iowa, where hundreds of homes were damaged in Cedar Rapids, Iowa City and other towns. Maren Stoflet, a hydrologist for the weather service in the Quad Cities, said that with the ground already soaked, all the new rain will run off into rivers.

The flooding is an ironic twist considering that the Mississippi was approaching record low levels all winter following months of drought. The Corps of Engineers worked feverishly to dredge the bottom of the river enough to keep barge traffic moving, though loads were limited for several months.

But late-winter snow and frequent rains have pushed river levels back to normal and beyond. The Mississippi on Wednesday was at or near flood stage at several spots north of St. Louis, slightly lower to the south.

The rain this week is expected to be furious at times, up to an inch an hour in some cases, Stoflet said. That could create flash flooding at smaller waterways. Tributaries to the Mississippi and Missouri rivers could also flood, and that water eventually pushes into the bigger rivers, which would crest next week.

Fuchs said if the rain falls as predicted, minor flooding would occur on the Missouri River in Missouri, while the Mississippi could rise 8 to 10 feet in some spots, including St. Louis.

Already in southeast Iowa, heavy rain Wednesday led to some road closures and rising creaks, according to hydrologist Maren Stoflet. And more rain was in the forecast.

Property buyouts, enhanced levees and flood walls will limit any damage, but several roads, thousands of acres of farmland and a few homes and businesses would be impacted and small levees could be overtopped.

Emergency management operators say they've begun to brace for the worst.

"I'll go into a full-scale flood fight," said John Hark, emergency management coordinator in Hannibal, Mo., the scenic hometown of Mark Twain.

The historic downtown area, including Twain's boyhood home, is protected by an earthen flood wall, and buyouts have removed flood-prone homes outside the wall's perimeter. But Hark said the excessive rain could create a sudden rise that would cause Bear Creek, a Mississippi River tributary, to back up, closing roads and threatening some homes.

About 30 miles to the south, Louisiana, Mo., has no flood wall. The downtown is far enough from the river that it is in no danger, but a flood reaching 8 to 10 feet above flood stage would push muddy river water over Highway 79 ? the main north-south highway through town ? and damage a few homes and businesses, City Administrator Bob Jenne said.

"We do have sand and all the bags already stockpiled in the event we need them," Jenne said. "Right now, it's wait and see."

Potentially worsening the flooding in the not-too-distant future is another strong snowstorm in the northern Plains, snow that will eventually melt and trickle into rivers. The newest system could drop as much as 15 inches of snow in western South Dakota by Thursday, forcing schools to close and making travel dangerous. It follows a weekend storm that dumped a single-day record 17.3 inches of snow on Bismarck, N.D.

The National Weather Service on Wednesday told Fargo, N.D., and Moorhead, Minn., residents to prepare for flooding along the Red River. It would be the fourth major flood in five years for an area that has about 200,000 people.

The weather service said there's a 40 percent chance the north-flowing river would top the 2009 record of 40.84 feet, or nearly 23 feet above the point when the river spills its banks. That would likely mean sandbagging for more than 200 homeowners in Fargo and about 40 homeowners in Moorhead.

Source: http://news.yahoo.com/rain-prompts-flood-worries-mo-ill-iowa-171620201.html

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Titan's methane: Going, going, soon to be gone?

Apr. 15, 2013 ? By tracking a part of the surface of Saturn's moon Titan over several years, NASA's Cassini mission has found a remarkable longevity to the hydrocarbon lakes on the moon's surface.

A team led by Christophe Sotin of NASA's Jet Propulsion Laboratory in Pasadena, Calif., fed these results into a model that suggests the supply of the hydrocarbon methane at Titan could be coming to an end soon (on geological timescales). The study of the lakes also led scientists to spot a few new ones in images from Cassini's visual and infrared mapping spectrometer data in June 2010.

Titan is the only other place in the solar system besides Earth that has stable liquid on its surface. Scientists think methane is at the heart of a cycle at Titan that is somewhat similar to the role of water in Earth's hydrological cycle -- causing rain, carving channels and evaporating from lakes. However, the fact that the lakes seem remarkably consistent in size and shape over several years of data from Cassini's visual and infrared mapping spectrometer suggests that the lakes evaporate very slowly. Methane tends to evaporate quickly, so scientists think the lakes must be dominated by methane's sister hydrocarbon ethane, which evaporates more slowly.

The lakes are also not getting filled quickly, and scientists haven't seen more than the occasional outburst of hydrocarbon rain at the moon over the mission's eight-plus years in the Saturn system. This indicates that on Titan, the methane that is constantly being lost by breaking down to form ethane and other heavier molecules is not being replaced by fresh methane from the interior. The team suggests that the current load of methane at Titan may have come from some kind of gigantic outburst from the interior eons ago possibly after a huge impact. They think Titan's methane could run out in tens of millions of years.

For more information on this finding and the lakes, visit http://saturn.jpl.nasa.gov/news/cassiniscienceleague/science20130412/ .

The Cassini-Huygens mission is a cooperative project of NASA, the European Space Agency and the Italian Space Agency. The Jet Propulsion Laboratory, a division of the California Institute of Technology, Pasadena, manages the mission for NASA's Science Mission Directorate, Washington, D.C. The visual and infrared mapping spectrometer team is based at the University of Arizona, Tucson.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/nVDWJF4RnTQ/130415164110.htm

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Tuesday, April 16, 2013

US official: 2 more explosives found at marathon

Medical workers aid injured people at the 2013 Boston Marathon following an explosion in Boston, Monday, April 15, 2013. Two explosions shattered the euphoria of the Boston Marathon finish line on Monday, sending authorities out on the course to carry off the injured while the stragglers were rerouted away from the smoking site of the blasts. (AP Photo/The Boston Globe, David L Ryan)

Medical workers aid injured people at the 2013 Boston Marathon following an explosion in Boston, Monday, April 15, 2013. Two explosions shattered the euphoria of the Boston Marathon finish line on Monday, sending authorities out on the course to carry off the injured while the stragglers were rerouted away from the smoking site of the blasts. (AP Photo/The Boston Globe, David L Ryan)

(AP) ? A senior U.S. intelligence official says two more explosive devices have been found near the scene of the Boston marathon where two bombs detonated earlier.

The official said the new devices were being dismantled.

It was not immediately clear what kind of devices had been found Monday. The official said the first two did appear to be bombs.

The official spoke on condition of anonymity because he was not authorized to discuss the findings publicly.

The official said it was not clear what the motive was or who may have launched the attack.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-15-US-Boston%20Marathon-Devices/id-2caec27b080f43208c1053d186e41098

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Add glamour and protection to your iPhone 5

I’ve seen “tire tread” cases for phones before, but never have I seen one with a touch of glamour. ?The Diamond Case for iPhone 5 from Musubo?is a “hybrid design” case. ?It has a hard, glossy, translucent panel that’s been formed with a diamond pattern. ?The edges are made of protective, impact-resistant TPU. ?The case [...]

Source: http://the-gadgeteer.com/2013/04/16/add-glamour-and-protection-to-your-iphone-5/

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Implantable, bioengineered rat kidney: Transplanted organ produces urine, but further refinement is needed

Apr. 14, 2013 ? Bioengineered rat kidneys developed by Massachusetts General Hospital (MGH) investigators successfully produced urine both in a laboratory apparatus and after being transplanted into living animals. In their report, receiving advance online publication in Nature Medicine, the research team describes building functional replacement kidneys on the structure of donor organs from which living cells had been stripped, an approach previously used to create bioartificial hearts, lungs and livers.

"What is unique about this approach is that the native organ's architecture is preserved, so that the resulting graft can be transplanted just like a donor kidney and connected to the recipient's vascular and urinary systems," says Harald Ott, MD, PhD, of the MGH Center for Regenerative Medicine, senior author of the Nature Medicine article. "If this technology can be scaled to human-sized grafts, patients suffering from renal failure who are currently waiting for donor kidneys or who are not transplant candidates could theoretically receive new organs derived from their own cells."

Around 18,000 kidney transplants are performed in the U.S. each year, but 100,000 Americans with end-stage kidney disease are still waiting for a donor organ. Even those fortunate enough to receive a transplant face a lifetime of immunosuppressive drugs, which pose many health risks and cannot totally eliminate the incidence of eventual organ rejection.

The approach used in this study to engineer donor organs, based on a technology that Ott discovered as a research fellow at the University of Minnesota, involves stripping the living cells from a donor organ with a detergent solution and then repopulating the collagen scaffold that remains with the appropriate cell type -- in this instance human endothelial cells to replace the lining of the vascular system and kidney cells from newborn rats. The research team first decellularized rat kidneys to confirm that the organ's complex structures would be preserved. They also showed the technique worked on a larger scale by stripping cells from pig and human kidneys.

Making sure the appropriate cells were seeded into the correct portions of the collagen scaffold required delivering vascular cells through the renal artery and kidney cells through the ureter. Precisely adjusting the pressures of the solutions enabled the cells to be dispersed throughout the whole organs, which were then cultured in a bioreactor for up to 12 days. The researchers first tested the repopulated organs in a device that passed blood through its vascular system and drained off any urine, which revealed evidence of limited filtering of blood, molecular activity and urine production.

Bioengineered kidneys transplanted into living rats from which one kidney had been removed began producing urine as soon as the blood supply was restored, with no evidence of bleeding or clot formation. The overall function of the regenerated organs was significantly reduced compared with that of normal, healthy kidneys, something the researchers believe may be attributed to the immaturity of the neonatal cells used to repopulate the scaffolding.

"Further refinement of the cell types used for seeding and additional maturation in culture may allow us to achieve a more functional organ," says Ott. "Based on this inital proof of principle, we hope that bioengineered kidneys will someday be able to fully replace kidney function just as donor kidneys do. In an ideal world, such grafts could be produced 'on demand" from a patient's own cells, helping us overcome both the organ shortage and the need for chronic immunosuppression. We're now investigating methods of deriving the necessary cell types from patient-derived cells and refining the cell-seeding and organ culture methods to handle human-sized organs."

Ott's team focuses on the regeneration of hearts, lungs, kidneys and grafts made of composite tissues, while other teams -- including one from the MGH Center for Engineering in Medicine -- are using the decellularization technique to develop replacement livers. Lead author of the Nature Medicine paper is Jeremy Song, MGH Center for Regenerative Medicine; additional co-authors are Jacques Guyette, PhD, Sarah Gilpin, PhD, Gabriel Gonzalez, PhD, and Joseph Vacanti, MD, all of the MGH Center for Regenerative Medicine. The study was supported by National Institute of Health Director's New Innovator Award DP2 OD008749-01.

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The above story is reprinted from materials provided by Massachusetts General Hospital, via EurekAlert!, a service of AAAS.

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Journal Reference:

  1. Jeremy J Song, Jacques P Guyette, Sarah E Gilpin, Gabriel Gonzalez, Joseph P Vacanti, Harald C Ott. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nature Medicine, 2013; DOI: 10.1038/nm.3154

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/f8_z1bYJGAQ/130414193433.htm

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Monday, April 15, 2013

FAA orders inspection of Boeing 737 tail planes

(Reuters) - The Federal Aviation Administration (FAA) has ordered an inspection of more than 1,000 U.S.-registered Boeing 737 jets to examine the tail planes for a potentially faulty part, which it said could cause pilots to lose control of the aircraft if it failed.

The airworthiness directive (AD) issued by the FAA calls on airlines and other operators to replace tail plane fixing pins with improved pins following concerns over how their protective surface coating was applied.

"We are issuing this AD to prevent premature failure of the attach pins, which could cause reduced structural integrity of the horizontal stabilizer to fuselage attachment, resulting in loss of control of the airplane," the FAA said in the directive issued on Monday.

The airworthiness directive was posted on the website of Federal Register (http://link.reuters.com/pyb47t) and was first reported by the Wall Street Journal late on Sunday.

The FAA said the inspection was "prompted by reports of an incorrect procedure used to apply the wear and corrosion protective surface coating to attach pins of the horizontal stabilizer rear spar."

FAA said its directive affects 1,050 aircraft flown by U.S. carriers and may cost up to $10.1 million across the fleet, or up to $9,627 per aircraft.

The directive applies to models including 737-600, 737-700, 737-700C, 737-800, 737-900, and 737-900ER series aircraft.

Boeing could not immediately be reached for comment by Reuters outside of regular U.S. business hours.

(Reporting by Sakthi Prasad in Bangalore; Editing by Greg Mahlich)

Source: http://news.yahoo.com/faa-orders-inspection-boeing-737-tail-planes-071555623--finance.html

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Dell S2340T


Until recently, Windows 8 certified touch-screen monitors have been relatively scarce, but not anymore. Monitor manufacturers such as Acer, Viewsonic, LG, and Planar have all announced multi-touch monitors that are designed to enhance the Windows 8 user experience. Not to be outdone, Dell has joined the fray with the release of the Dell S2340T, a 23-inch IPS monitor featuring 10-point touch technology and a handful of useful features, including a webcam and USB 3.0 and Ethernet connectivity. More importantly, it delivers good color and grayscale accuracy and responsive touch functionality. However, it's the most expensive 23-inch touch-screen monitors we've reviewed to date, and it only has two video inputs and lacks VESA wall mounting capabilities.

Design and Features
As with the Acer T232HL and Viewsonic TD2340, the S2340T boasts a slick tablet-like design. The 1,920-by-1,080 IPS panel sports a glossy (and reflective) edge-to-edge glass coating over black borders. The requisite Dell logo is positioned along the lower edge of the display and there five buttons on the right side of the cabinet. A two-megapixel webcam and dual microphone array is embedded in the glass above the panel.

The use of edge-mounted LED backlighting allows for a very thin (0.8-inch) cabinet, which is supported by a glossy black square base and a silver dual hinge mechanism. The hinge provides height and tilt adjustability and allows you to lay the panel flat so it is parallel with the desktop surface. Unlike the Acer and Viewsonic model, the S2340T doesn't have VESA-compliant mounting holes. That's because the all of its ports are located in the base.

You only get two video inputs (HDMI and DisplayPort), both of which are located at the rear of the base. They share space with three USB 3.0 ports (one upstream, two downstream), an Ethernet port (a rarity among desktop monitors), and the power jack. On the right side of the base are two more downstream USB 3.0 ports and on the left side are headphone and microphone jacks. The base acts as a docking station for your notebook, delivering Ethernet, USB, and audio connectivity via a single USB cable. It is also home to two relatively loud 5-watt speakers.

Four of the five aforementioned buttons are used to access and navigate the settings menus (the fifth button is the power switch). The S2340T uses the same excellent on-screen labeling system that is used by Dell's UltraSharp U3014 and UltraSharp U2713HM models; touching any button launches a menu that corresponds to each button, making it easy to work your way through the settings menus.

The S2340T gives you seven picture presets including Standard, Multimedia, Game, Movie, Text, Warm, and Cool. There's also a Custom Color preset for users who prefer to create their own color mode. Brightness, Contrast, Hue, and Saturation adjustments are also available, as are Sharpness and Aspect Ratio settings. The Energy Smart option enables dynamic dimming that reacts to the amount of bright areas on the screen, and the Green Mode option helps conserve power by disabling advanced USB features.

Dell covers the S2340T with an extraordinary four year warranty. The monitor ships with HDMI, DisplayPort, and USB (upstream) cables as well as a resource CD and a Quick Start Guide.

Performance
The S2340T's multi-touch screen was a pleasure to use; pinching, tapping, and stretching gestures worked perfectly as did swipe and scroll movements. Entering text using the on-screen keyboard was comfortable, especially when the panel was tilted backward.

Color accuracy was good but not perfect. On the CIE (International Committee on Illumination) chromaticity chart below, the closer each color dot is to its corresponding box, the better the color accuracy. Reds and blues were very accurate but greens were a little off.

This is not uncommon with desktop monitors, and in this case the flaw does not translate to tinting or skewed skin tones. In fact, image quality was superb while watching blu-ray movies; flesh tones in the movie 2012 were natural looking and colors were deep and well defined. That said, if you absolutely must have spot-on color accuracy you can try calibrating the monitor or consider investing in a professional grade monitor such as the NEC MultiSync PA301W or Dell U3014.

The panel did a good job of rendering each shade of gray on the DisplayMate 64-Step Grayscale test, but as was the case with the Viewsonic TD2340, the darkest shade of gray could have been a bit darker. Viewing angles were typical of an IPS panel; colors remained intact from any angle and the picture suffered no significant loss of luminance when viewed from the top, bottom, or side.

The S2340T averaged 26 watts of power usage during testing, which is on par with the 23-inch Acer and Viewsonic touch-screen models. I was able to lower that number to 23 watts by enabling the Energy Smart dynamic dimming option but couldn't get it as low as the Viewsonic's Optimize ECO mode (16-watts) or the Acer's ECO mode (18-watts).

The Dell S2340T is a sharp-looking 23-inch touch-screen monitor that is optimized for Windows 8. It offers robust IPS color quality, solid grayscale performance, and outstanding 10-point projected capacitive touch technology. The addition of a webcam and an Ethernet port are nice touches, but a third video input would be welcome here. Moreover, at $700 it's very expensive for a 23-inch monitor, even one with touch-screen capabilities and a generous feature set. Our Editors' Choice for touch-screen monitors, the Acer T232HL, also offers solid IPS performance, responsive 10-point touch technology, and a USB hub, but it doesn't double as a docking station or have a webcam. However, it's almost $150 cheaper than the S2340T.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/CBmfloNA64U/0,2817,2417713,00.asp

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Saturday, April 13, 2013

Cell-destroyer that fights and promotes TB reveals what's behind its split identity

Cell-destroyer that fights and promotes TB reveals what's behind its split identity

Friday, April 12, 2013

Tumor necrosis factor ? normally an infection-fighting substance produced by the body? can actually heighten susceptibility to tuberculosis if its levels are too high.

University of Washington TB researchers unravel this conundrum in a report this week in Cell.

Their study shows how excess production of this disease-cell destroyer at first acts as a TB germ killer. But later the opposite occurs: too much tumor necrosis factor encourages TB pathogens to multiply in the body.

In addition to figuring out some reasons behind this back-pedaling, the scientists learned that certain combinations of drugs already available for other conditions can curtail the shift from anti-TB to pro-TB.

The drug combination revealed in this study, the authors noted, "has the potential to revert some cases of hypersusceptibility to hyperresistance."

The scientists were Francisco Jose Roca Soler, of the UW Department of Microbiology, and Lalita Ramakrishnan, UW professor of microbiology, medicine and immunology. A recipient of the National Institutes of Health Director's Pioneer Award, Ramakrishnan is recognized for her work on how the TB pathogen and its hosts' cells interact to cause disease.

These studies are conducted in zebrafish, an animal model for tuberculosis. The fish's embryos and small fry are transparent. Researchers can see through their skin to observe their organs, tissues and cells and the internal appearance of some infections, for example, the bacterial cording of TB.

Roca and Ramakrishnan explained that TB had traditionally been thought of as a disease of failed immunity. However, more recent studies from their lab and other labs, both in zebrafish and in humans, have suggested that it also can result from too strong of a defensive inflammatory response.

"While tumor necrosis factor is a critical host defense against tuberculosis," Roca and Ramakrishnan noted, "an excess of this factor is also implicated in the development of the disease in zebrafish and in humans."

Variations in a specific location of the zebrafish genome can cause either too much or too little tumor necrosis factor to be produced, depending on the type of variation. In either case, deficiency or overabundance, zebrafish become prone to tuberculosis.

In both cases the scavenger cells, or macrophages, that are trying to clear away the TB pathogens by ingesting them, die and burst open. They are like torn vacuum cleaner bags spilling their dirty contents.

When the TB bacteria escape the confines of the scavenger cells, "they grow exuberantly in the extracellular environment," Roca and Ramakrishnan said.

Researchers needed to work out the differences between TB susceptibility caused by too high or too low tumor necrosis factors because the distinction is vital to treatment decisions. Only patients whose genetics made them launch a pro-inflammatory response, benefited from steroid treatment, previous studies have shown. Steroids can increase the chance of death among TB patients with a weak inflammatory response.

In the present study, Roca and Ramakrishnan elucidated the molecular pathways by which too much tumor necrosis factor at first rapidly promotes macrophages to go after TB bacteria, and then turns around and forces the hard-working macrophages to die and expel their captives.

They found that both the microbiocidal activity, and the death of the macrophages, resulted from upping the production of reactive oxygen species by the mitochondria inside the macrophages. Mitochondria are the energy-generating power plants of living cells.

Tumor necrosis factor inside of infected macrophages induces reactive oxygen species from the mitochondria. These are the chemicals responsible for cell damage from oxidative stress.

Early on, reactive oxygen species can be beneficial. Initially their presence encourages the macrophages to destroy pathogens. As they accumulate, however, they promote self-harm.

Suddenly the macrophage is programmed to self-destruct. The reactive oxygen species carry out the death sentence by modulating a pathway for a substance called cyclophilin D, which sets the stage for the demolition of mitochondria.

Reactive oxygen species also play a role in acid sphingomyelinase-mediated ceramide production. This waxy substance occurs in cell membranes. One of its many roles is regulating signals for cell death.

The researchers were able to convert the high tumor necrosis factor state to become resistant to tuberculosis. They did so by genetically blockading both cyclophilin D and acid sphingomyelinase in previously susceptible zebrafish.

Similarly, they discovered that the drug combination of alisporivir, a cyclophilin D-inhibiting drug, and desipramine, an antidepressant that inactivates acid sphingomyelinase, also reverses susceptibility to TB in zebrafish prone to tumor necrosis factor excess.

Essentially, the experiments suggest that preventing cell death in TB infected macrophages can prolong their capacity to attack TB pathogens.

A longer-living army of macrophages, filled with the microbiocidal reactive oxygen species, will destroy the TB pathogens inside them and make the host highly resistant to tuberculosis.

Because excessive amounts of tumor necrosis factor are implicated in several inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, sarcoidosis, and Crohn's, the authors noted, "The findings may be useful for understanding diseases in addition to tuberculosis."

###

University of Washington: http://www.uwnews.org

Thanks to University of Washington for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127722/Cell_destroyer_that_fights_and_promotes_TB_reveals_what_s_behind_its_split_identity

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